Complexity of Gene Expression Evolution after Duplication: Protein Dosage Rebalancing
نویسندگان
چکیده
منابع مشابه
Complexity of Gene Expression Evolution after Duplication: Protein Dosage Rebalancing
Ongoing debates about functional importance of gene duplications have been recently intensified by a heated discussion of the "ortholog conjecture" (OC). Under the OC, which is central to functional annotation of genomes, orthologous genes are functionally more similar than paralogous genes at the same level of sequence divergence. However, a recent study challenged the OC by reporting a greate...
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Rapid divergence of gene copies after duplication is thought to determine the fate of the copies and evolution of novel protein functions. However, data on how long the gene copies continue to experience an elevated rate of evolution remain scarce. Standard theory of gene duplications based on some level of genetic redundancy of gene copies predicts that the period of accelerated evolution must...
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Alternative splicing and gene duplication are two major sources of proteomic function diversity. Here, we study the evolutionary trend of alternative splicing after gene duplication by analyzing the alternative splicing differences between duplicate genes. We observed that duplicate genes have fewer alternative splice (AS) forms than single-copy genes, and that a negative correlation exists bet...
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Recent studies reveal that transmenbrane (TM) topology (the number of TM segments (TMSs), the TMS position and the orientation of TMS to the membrane lipid bilayer) evolves by internal gene duplication [1, 6]. A large number of TM proteins, such as Bacteriorhodopsin, Na/Ca exchanger and the major facilitator superfamily, have been recognized to have internal repeats that presumably has arisen f...
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ژورنال
عنوان ژورنال: Genetics Research International
سال: 2014
ISSN: 2090-3154,2090-3162
DOI: 10.1155/2014/516508